A. Nasal decongestant sprays like Afrin (oxymetazoline) have a clear warning: “Do not use for more than three days. Reddit; Wechat; Abstract. I'm also an admitted afrin addict. Afrin nasal spray, for example, is an over the counter product containing this oxymetazoline hcl compound. … I still use afrin on occasion, but I'm more careful about not using it on consecutive days. Here is what I did. Yeah, I have. Luckily, I still have a 100% success rate with continued afrin use at night. Find out more about the different types of nasal spray and how to use them safely. I once tried to break the afrin … My doctor had to ween me off it with a prescription antihistamine. Afrin really works well but 24 hours later you have a boomerang effect... you need it again. Oxymetazoline nasal spray is not FDA approved for use in children less than 6 years; however, its safety and efficacy are widely accepted, and it is in widespread use in children prior to procedures that may lead to epistaxis. The weird thing is that the only active ingredient is oxymetazoline, which is a steroid, not an amphetamine, so I question this person's doctor and withdrawal statement (other than congestion of course). I had experience with the one with oxymetazoline hcl, so I thought I would try phenylephrine. While Afrin can be very effective, it comes with quite a few side effects. The first two nights were hell, but it got better. This was the one with phenylephrine in it. Do not use 2 doses at the same time or extra doses. Some read the warning label: "Do not use this product if you have heart disease, high blood pressure, thyroid disease, diabetes, or difficulty in urination due to enlargement of the prostate gland unless directed by a doctor." Nasal sprays can relieve a congested nose or throat, but people can develop a dependence with some types. The good effect won't last as long and you need to use it again and sooner! Oxymetazoline hydrochloride is an agonist at A1 and A2 adrenergic receptors.This compound is primarily found in nasal decongestant products because it causes vasoconstriction of the nasal passage and thus allows proper airflow when nasal congestion occurs. I've only been on the Afrin train for about 4 months or so, so hopefully I can get out fairly easy, but I have all the telltale symptoms. Use only as directed. I have 100% clarity all day long and my sinuses literally close off the second I hit the pillow. I put about 20 drops on a plate and then microwaved it to evaporate it, then I scraped it up with a knife. We report a case of intraoperative oxymetazoline toxicity in a 4‐year‐old boy that led to a hypertensive crisis. Afrin’s packaging—somewhat ineffectively—cautions against using the drug for more than a few days at a time. If you use Afrin Nasal Spray (oxymetazoline (nasal)) on a regular basis, use a missed dose as soon as you think about it. Oxymetazoline and xylometazoline are both used as nasal mucosa decongesting α‐adrenoceptor agonists during a common cold. It can cause temporary burning, stinging, dryness, runny nose, and sneezing. For nasal congestion due to colds and allergies, millions of Americans reach for an over-the-counter decongestant to clear a stuffy nose. If it is close to the time for your next dose, skip the missed dose and go back to your normal time. However, one of the main side effects is rebound congestion, also commonly referred to as nasal spray addiction. Use only as directed. This is partially due to the fact that prolonged use can cause nasal swelling that effectively prevents the product from working as intended as a nasal decongestant. Today, I will use Afrin but I dilute it 1/4 Aftin to 3/4 water and put it in an old nose spray atomizer. I used it for several months a couple of years ago and it was pretty hard to quit. 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