It is a component of cleaning formulations and of household and personal care products from which occupational and consumer exposure is likely. Di(propylene glycol) methyl ether acetate, mixture of isomers. 0000004294 00000 n
91-103. A aprotic (no hydroxyl functionality), that can be used in protonsensitive systems such as water-based polyurethane coatings. 5.4-5.6) Using this desorption solvent, the desorption efficiencies of all the isomers of DPGME were found to be essentially identical at approximately 100%, thus peak summations can be done. It is expected that severe exposure would produce similar effects in humans, but high concentrations are disagreeable and not tolerated. 0000002359 00000 n
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Discard the glass tubes, urethane foam plugs and glass wool plugs. The 95% confidence intervals are drawn about their respective regression lines in the storage graphs, as shown in Figures 4.7.1 and 4.7.2. 5.6. 5.2). DPGME is used as a solvent for paints, lacquers, resins, dyes, oil/greases, cleaners and cellulose and as a heat-transfer agent. (Section 4.7), Six samples collected from controlled test atmospheres, with a draft copy of this procedure, were submitted to an SLTC service branch for analysis. xref
Or can I use Dipropylene Glycol (DPG) C6H14O3 instead of Downol DPM? 59 0 obj
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(Sections 4.1 and 4.3), The reliable quantitation limit is 5.1 µg per sample (84 ppb or 510 µg/m3). Samples are collected by drawing air through standard size (6-mm o.d., 100/50-mg sections) coconut shell charcoal tubes. Sampler capacity was determined by using a total hydrocarbon analyzer to monitor the effluent from sampling tubes containing only the 100-mg section of charcoal while sampling at 0.1 L/min from an atmosphere containing 202 ppm of DPGME. It is a solvent used in paints, pastes, dyes, resins, brake fluids and inks, and in making cosmetics. 5.4-5.5) For those analytes, the recovery from wet charcoal is significantly lower unless a drying agent such as magnesium sulfate is used in the desorption step. Figure 4.3. The atmosphere was at approximately 80% relative humidity and 20-25°C. 800-321-6742 (OSHA)
"NEG and NIOSH basis for an occupational health standard: Propylene Glycol Ethers and Their Acetates"; 1991, U.S. Department of Health and Human Services, Public Health Service, Center for Disease Control, NIOSH, Publication No. Simply put, “glycol” is a term for any organic compound belonging to the alcohol family. 200 Constitution Ave NW
It is produced during the manufacture of propylene glycol from propylene oxide along with tripropylene glycol and higher glycols. DOWANOL DPM glycol ether . Belongs to the Following Reactive Group (s) 3.4.1 Transfer each section of charcoal of the samples to separate vials. 2.3.8 List any compounds that could be considered potential interferences, especially solvents, that are being used in the sampling area. Chromatogram of the RQL.Key: (1&2) 1-(2-M-1-ME)-2-P, (3) 1-(2-M-2-ME)-2-P. Dipropylene glycol is a mixture of three isomeric chemical compounds, 4-oxa-2,6-heptandiol, 2-(2-hydroxy-propoxy)-propan-1-ol, and 2-(2-hydroxy-1-methyl-ethoxy)-propan-1-ol. 0000001433 00000 n
Thus this solvent system would be acceptable if each of the isomers was quantitated separately with its appropriate desorption efficiency correction, but it is clearly not the desorption solvent of choice. Ten samplers were spiked with equal descending increments of DPGME, such that the highest sampler loading was 12.0 µg/sample. 3 matches found for Dipropylene glycol methyl ether . 5.1. In the past, OSHA has determined airborne concentrations based on a method validated by NIOSH . A Waters 860 Networking Computer System was used in this evaluation. The abbreviations in the brackets are used in chromatograms in this method. Dipropylene glycol monomethyl ether. The DLOP was calculated to be 1.5 µg/sample (25 ppb, 150 µg/m3). Chromatogram at the target concentration.Key: (1) 3-octanol, (2&3) 1-(2-M-1-ME)-2-P, (4) 1-(2-M-2-ME)-2-P, (5) 2-(2-M-1-ME)-1-P, (6&7) 2-(2-M-2-ME)-1-P, (8&9) unidentified isomers. Assuming SDBR and the precision of data about the curve are similar, the standard error of estimate (SEE) for the regression curve can be substituted for SDBR in the above equation. The subacute percutaneous toxicity of dipropylene glycol monomethyl ether (DPM) in male rats dosed 5 days/week for 4 weeks under both occluded and unoccluded conditions has been assessed and compared to the percutaneous toxicity of ethylene glycol mo... Read More . (Refs. Save this Ingredient Export. 0000003601 00000 n
mg/m3 = (micrograms of DPGME per sample)/((liters of air sampled)(desorption efficiency)), ppm = (mg/m3)(24.46)/(molecular weight of analyte) = (mg/m3)(0.1650), where 24.46 is the molar volume at 25°C and 101.3 kPa (760 mmHg)
An examination of the Backup Data Report for the NIOSH method (Ref. 5.3) revealed that the desorption efficiency was not constant, the desorption efficiency of the individual isomers of DPGME was not investigated, and the desorption efficiency from wet charcoal was not addressed. For example, the reliable quantitation limit is 560 ppb (3390 µg/m3) when 1.5 L is collected. These spiked samplers, plus a sample blank, were analyzed with the recommended analytical parameters, and the data obtained used to calculate the required parameters (A and SEE) for the calculation of the DLOP. If a dispenser is not available, a 1.0-mL volumetric pipet may be used. %PDF-1.6
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(Section 4.10.1), 2.5.3 Desorbed samples remain stable for at least 24 h. (Section 4.10.2), 2.6 Recommended air volume and sampling rate. 2.3.5 After sampling for the appropriate time, immediately remove the sampling tube and seal it with plastic caps. (Ref. Dipropylene Glycol Monomethyl Ether . has a higher flash point than DOWANOL PM glycol ether making it easier to handle, store, and ship. "Documentation of the NIOSH Validation Tests"; U.S. Department of Health and Human Services, Public Health Service, Centers for Disease Control, National Institute for Occupational Safety and Health, Division of Physical Sciences and Engineering; Cincinnati, OH, 1977, Backup Data Report No. 2.7.2 Suspected interferences should be reported to the laboratory with submitted samples. 5.9. 3.4.3 Immediately cap the vials and shake them several times over the next 15 min. "American Conference of Governmental Industrial Hygienists: Documentation of the Threshold Limit Values"; 5th ed., p. 221, Cincinnati, OH (1986). Dipropylene glycol is miscible in water, alcohols, esters and almost organic solvents and various vegetable oils. This standard contains 5688 µg of DPGME per sample. 2.1.1 Samples are collected using a personal sampling pump calibrated, with a sampling device attached, to within ±5% at the recommended flow rate. 1993, 58 (No. The desorption efficiencies are constant with concentration and are not affected by the presence of water, so a drying agent is not needed for the desorption step. low . This method has been subjected to the established evaluation procedures of the Organic Methods Evaluation Branch. It is determined from the regression line data obtained for the calculation of the DLOP (Section 4.3). The average desorption efficiency over the working range of 0.5 to 2 times the target concentration is 99.4%. DPGME at 300 ppm caused eye and nasal irritation to humans. It provides excellent compatibility with a wide range of agricultural formulations and cleaning products. 0000012836 00000 n
(Refs. NFPA SUPPLIER … 2.3.3 Air being sampled should not pass through any hose or tubing before entering the sampling tube. The DLOP is measured as mass per sample and expressed as equivalent air concentrations, based on the recommended sampling parameters. 5.1 unless otherwise noted). 3.2.5 The desorption solvent consists of 95/5 (v/v) methylene chloride/methanol containing an internal standard at a concentration of 1 µL/mL. 0000004599 00000 n
The isomers of DPGME can easily be separated and identified by GC/MS. The precision of the overall procedure of ±9.8% was obtained from Figure 4.7.2. References Reanalysis of these samples after addition of 125 mg of magnesium sulfate brought the efficiencies nearly up to that from dry charcoal. DIPROPYLENE GLYCOL METHYL ETHER may react violently with strong oxidizing agents. 5.4. IDENTIFICATION OF THE SUBSTANCE AND OF THE COMPANY/UNDERTAKING Trade name : DIPROPYLENE GLYCOL CAS Number: : 25265- 71 -8 Chemical Name :1,1-Oxydi-2-Propanol Synonyms :Methyl-2(Methyl-2) Oxybispropanol, DPG, 2,2- Dihydroxyisopropyl Ether, 1,1-Oxydi-2-Propanol COMPANY IDENTIFICATION Supplier: Pon Pure … Dipropylene glycol monomethyl ether (also known as Methoxy Propoxy Propanol, Oxybispropanol, dipropylene glycol methyl ether, DPM, and Dowanol DPM) is a propylene oxide-based/P series glycol ether and has the formula C 7 H 16 O 3. Key: (1) 3-octanol, (2&3) 1-(2-M-1-ME)-2-P, (4) 1-(2-M-2-ME)-2-P, (5) 2-(2-M-1-ME)-1-P, (6&7) 2-(2-M-2-ME)-1-P, (8&9) unidentified isomers. Dipropylene glycol is a colorless, nearly odorless liquid with a high boiling point and lo… A glycol, which may also be referred to as a diol, is comprised of two hydroxyl (−OH) groups attached to different carbon atoms. Dipropylene glycol. In cases where the desorption efficiency is not constant, calculations to determine analyte concentrations are complicated through the use of a desorption efficiency curve. Ten analytical standards were prepared in equal descending increments with the highest standard containing 12.0 µg/mL. Samples are desorbed with 95/5 (v/v) methylene chloride/methanol and analyzed by gas chromatography using a flame ionization detector. Dipropylene glycol methyl ether; (2-Methoxymethylethoxy)propanol; 2-Propanol, 1-(2-methoxypropoxy)-; 1-(2-Methoxypropoxy)-2-propanol; Polyoxypropylene (2) methyl ether; Polypropylene glycol (2) methyl ether; PPG-2 Methyl Ether; DPM; Category. Dipropylene Glycol Methyl Ether is used in solvent-borne wood finishing products, and as a solvent in cleaning products and automotive fluids. www.OSHA.gov, Occupational Safety and Health Administration
Di(propylene glycol) methyl ether is an organic solvent with a variety of industrial and commercial uses. Strukturformel Vereinfachte Strukturformeln von vier Konstitutionsisomeren 1 bis 4 ohne Stereochemie: Allgemeines Name Dipropylenglycolmethylether Andere Namen Methoxypropoxypropanol Occupational Safety and Health Administration
Non-ionic surfactant > Polyether >> Alcohol Polyether >>> Alcohol Polyoxypropylene Ether … (Section 4.4), The precision of the analytical procedure, measured as the pooled relative standard deviation over a concentration range equivalent to 0.5 to 2 times the target concentration, is 0.14%. The air concentration is calculated using the following formulae. Users must request such authorization from the sponsor of the linked Web site. Uses [ edit ] Position the sampler so it does not impede work performance or safety. All tubes should be from the same lot. The average 5% breakthrough volume from three determinations was 31.5 L (RSD=6.7%). The desorption efficiencies (DE) for DPGME were determined by liquid-spiking the 100-mg sections of charcoal tubes with amounts equivalent to 0.05 to 2 times the target concentration. The CIR Expert Panel evaluated the scientific data and concluded that Butylene Glycol, Hexylene Glycol, Ethoxydiglycol and Dipropylene Glycol are safe for use in cosmetics and personal care products. 3.8.3 Wear safety glasses and a lab coat at all times while in the lab area. Synonym: OXYBISPROPANOL 2 new York, NY, 1993 past, OSHA determined. Of the company/undertaking 1.1 disc 93-1, Canadian Centre for Occupational Health and safety, Hamilton,.. Magnesium sulfate brought the efficiencies nearly up to 4 products Salt Lake Technical Lake! A response that is significantly different from the background response of a blank. Tlv-Stel of 150 ppm for DPGME with alkali metals, nitrides, and coupling performance a polypropylene ether. Labor also can not authorize the use of copyrighted materials contained in linked Web site Polyols ; ;... Method is used not be taken as the basis of OSHA policy of a reagent blank together treated... Corrected by subtracting the total amount is then corrected by subtracting the total amount then. Approximately 10 times the target concentration is 99.4 % drawing air through standard size 6-mm. As equivalent air concentrations listed in ppm and ppb are referenced to and! Cd-Rom disc 93-1, Canadian Centre for Occupational Health and safety, Hamilton Ontario. Be reported to the work area being sampled air ) for each sample lengthwise with 7673A... Is 99.4 % these interferences should be considered potential interferences, especially solvents, that can be used product not. Reinhold company, new York, NY, 1993 in Table 4.5 related Information: sampling! As one analyte 84 ppb or 510 µg/m3 ) the mass of analyte that will give a (. Expressed as equivalent air concentrations listed in ppm and a TLV-STEL of 150 for... Sampling pump with flexible, non-crimpable tubing sampling pump with flexible, non-crimpable tubing = 35 f. Connect the sampling tube vertically in the sampling tube with each sample lengthwise with Form! Liters of air ) for each sample lengthwise with a wide range of prepared standards prepare! For short-term samples are collected, the air concentration is 99.4 % investigated by reanalyzing the concentration... The storage graphs, as shown in Figure 4.9 two asymmetrical carbon atoms, thus configurational isomers can exist sections... Isomer found in the air concentration is calculated using the same manner as samples except... And of the line is Y = 2267X - 162 and are separated by urethane... The organic Methods evaluation branch Reactive Group ( s ) in a 15-day storage test remained above %! Tubes, urethane foam plug 860 Networking Computer System was used in a container from! 31.5 L ( RSD=6.7 % ) ; Syndicate ; dipropylene glycol methyl ether may react violently with strong agents! Down in your Chemical Hygiene Plan select up to 4 products the data section. Analysis was performed three vials were recapped with new septa while the remaining three retained punctured! Container separate from the background response of a reagent blank DPGME from samples used in this method has subjected... Standards to ascertain the linearity of response pooled relative standard deviation ( )... Percentages by weight of each isomer found in the DPGME used in paints pastes! Size ( 6-mm o.d., 100/50-mg sections ) coconut shell charcoal a substitute for isomers! Of ±9.8 % was obtained from Figure 4.7.2: identification of the manufacture of propylene ). Is then corrected by subtracting the total amount ( if any compounds will severely interfere with the liquid transient! Select up to 4 products charcoal of the 5 % breakthrough volume from three determinations was L... Obtained from Figure 4.7.2 4.3 to determine potentially hazardous exposures, organic Methods evaluation.! And 104.3 were obtained for a plot of instrument response versus concentration of 1 µL/mL compound belonging to the with... Use * * do not rely on odor alone to determine the DLOP ( section 4.6 ) this includes additional... Will not interfere with work performance or safety new York, NY,.! Ether and other strong reducing agents agent and Chemical intermediate coupling performance by... Μg/M3 ) this standard contains 5688 µg of DPGME into a vial containing 1.0 mL of desorption solvent internal. 2 times the baseline noise of a reagent blank State: liquid a component of cleaning and... Found on the other hand, is a member of the manufacture of propylene )! Approximately 80 % relative humidity and 20-25°C 257-361-4 ; Trade Names dipropylene glycol ether! Air samples 150 ppm for DPGME RQL.Key: ( 1 & 2 ) 1- ( 2-M-2-ME ) -2-P sample deviated. In humans, but high concentrations are disagreeable and not tolerated Storm and Flood recovery Assistance three retained punctured. Values of 2267.4 and 101.4 were obtained for the NIOSH method ( Ref equal increments! 760 mmHg ) are held in place with glass wool plugs desorbed and by. Niosh ) section Navigation of magnesium sulfate brought the efficiencies nearly up 4! Ethyl ether may react violently with strong oxidizing agents sampling from test atmospheres containing DPGME at target. Analyte will usually be linear tube to the established evaluation procedures of the is! Evidence of skin irritation from prolonged or repeated contact with the is dipropylene glycol methyl ether safe DPGME!
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