Puppies 2 to 8 weeks old treated once at up to 20x the therapeutic dose (200 mg/kg) showed no adverse effects. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Veterinary formulations: Advantage Multi® (Bayer). Advantage Multi for Dogs is indicated for the prevention of heartworm disease caused by Dirofilaria immitis and the treatment of Dirofilaria immitis circulating microfilariae in heartworm-positive dogs. The adult dosage for most cats is 0.4 mL of the imidacloprid oil. Dogs with this mutation may develop signs of severe avermectin toxicity if they ingest this product. b Although there is no specific antagonist for avermectin toxicity, even severely affected dogs have completely recovered from avermectin toxicity with intensive veterinary supportive care. Using the correct dosage about 15 CC's will work... like i said above , it didn't work very well for me on ticks, but it will kill fleas. One dog exhibited shaking (nervousness) 1 hour post-dosing. Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. Assurity Plus Spot On works rapidly to control fleas, killing over 98% of adult fleas within 12 hours of application. Recommended dosage-Been using the Bayer tree & shrub, 1.47% imidicloprid product here since early spring. It is frequently used in combination with other medications to treat a variety of parasites. Overdose is rare and no adverse effects have been reported at even up to 5 times the recommended dose. Administering the same dose for three consecutive months increased the level of protection to 44.4%, higher than that achieved with a single dose of moxidectin at 12 µg/kg (33.3%) and approaching the efficacy of one dose at 24 µg/kg (53.2%) (Table 1); however, all dogs in all groups were infected with HW regardless of dose and regimen used. The signs resolved without intervention by day 10 post-application. Cats over 18 pounds should be treated with the appropriate combination of tubes. Moxidectin is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus. 56. or less, place the tip of the tube on the skin and apply the entire contents directly on the exposed skin at one spot between the shoulder blades. Have person sip a glass of water if able to swallow. It is also not recommended for use in. Both have the same formula containing 1.47 percent Imidacloprid just like the Bayer Tree and Shrub Insect Control. Multiply 0.045 times your dogâs weight for dose The recommended minimum dose is 4.5 mg/lb (10.0 mg/kg) imidacloprid and 0.45 mg/lb (1.0 mg/kg) moxidectin, once a month, by topical administration. Stiff hair, a damp appearance of the hair, pink skin, or a slight powdery residue may be observed at the application site on some animals. Imidacloprid and moxidectin may interact with other medications. The chemical name for imidacloprid is 1-[(6-Chloro-3-pyridinyl)methyl]-N-nitro-2-imidazolidinimine. Topical imidacloprid/moxidectin combination treatment administered 3 times at 28-day intervals, or more frequently, did not eliminate mites from most treated dogs. No clinical abnormalities were observed. Available for Android and iOS devices. (See WARNINGS.). Dermal Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered topically at 3 and 5X the recommended dose every 28 days for 3 treatments to Collies which had been pre-screened for avermectin sensitivity. Monthly imidacloprid application of 7.5 to 10 mg/kg will rapidly kill existing and reinfesting flea infestations on dogs and break the flea life cycle by killing adult fleas before egg production begins. ©Copyright 1999 - 2021. This is a common over-the-counter medication used to prevent fleas and heartworms in dogs as well as ear mites in cats. Select one or more newsletters to continue. Three dogs treated with Advantage Multi for Dogs in a dosing regimen with melarsomine dihydrochloride died of pulmonary embolism from dead and dying heartworms. Six dogs vomited within 1 hour of receiving the test article, 2 of these dogs vomited again at 2 hours, and 1 dog vomited again up to 18 hours post-dosing. In dogs, injectable moxidectin is dosed at 0.023 mg per pound (0.05 mg/kg) intramuscularly every 6 months. Following the first treatment with Advantage Multi for Dogs alone, two dogs experienced adverse reactions (coughing, vomiting, and dyspnea) that required hospitalization. Imidacloprid is a chloronicotinyl nitroguanidine insecticide. In avermectin sensitive dogs,a the signs may be more severe and may include coma and death.b. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. a Some dogs are more sensitive to avermectins due to a mutation in the MDR1 gene. At 5X, one dog was observed vomiting three hours after the second treatment. All Rights Reserved. Tubes/pipettes are available in sizes of 0.4 ml (for dogs 3-9 pounds), 1 ml (for dogs 9.1 â 20 pounds), 2.5 ml (for dogs 20.1 to 55 pounds), and 4 ml (for dogs over 55.1 to 88 pounds). Treatment and Control of Sarcoptic Mange: For the treatment and control of sarcoptic mange caused by Sarcoptes scabiei var. Be certain to complete the prescription unless specifically directed otherwise by your veterinarian. Flea Treatment: For the treatment of flea infestations, Advantage Multi for Dogs should be administered at one-month intervals. While holding the tube in an upright position, remove the cap from the tube. Parasitic infections are common and include external parasites (fleas, ticks, mites) and internal parasites (intestinal worms, lungworms, heartworms). It is supplied in the form of applicator tubes with 0.4 ml, 1.0 ml, 2.5 ml and 4.0 ml for dogs and 0.4 ml or 0.8 ml for cats. We comply with the HONcode standard for trustworthy health information -, Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs Indications, Warnings and cautions for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs, Direction and dosage information for Advantage Multi (imidacloprid + moxidectin) Topical Solution for Dogs. For dogs weighing 20 lbs. 5. Prepare the dose of imidacloprid This is one of the trickier parts of this treatment regimen. Start to kill adult fleas within 1 hour. Advantage Multi is protected by one or more of the following U.S. patents: 6,232,328, and 6,001,858. Advantage Multi for Dogs is also indicated for the treatment and control of the following intestinal parasites: Do not administer this product orally. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. Keep out of reach of children. One dog, treated with Advantage Multi for Dogs and melarsomine dihydrochloride, experienced pulmonary hemorrhage and responded to supportive medical treatment. Do not induce vomiting unless told to do so by the poison control center or physician. advantus ® (imidacloprid) is an FDA-approved, flavored soft chew that fights fleas fast. Avoid contact with skin. For cats, tubes/pipettes are available in sizes of 0.23 ml ( for cats and kittens from 2 –5 pounds) 0.4 ml (for cats 5.1 – 9 pounds) and 0.8 ml (for cats 9.1 18 pounds). One dog showed signs of treatment site irritation after application. Dogs should be older than 7 weeks of age and cats older than 8 weeks of age. Not for human use. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Dermal LD 50 of technical imidacloprid for rats is more than 5000 mg/kg. Advantage Multi ® for Dogs (10 % imidacloprid + 2.5 % moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. The duration of administration depends on the condition being treated, response to the medication and the development of any adverse effects. It is supplied as a topical solution that collects in the oils of the skin and in hair follicles. The dose of imidacloprid is based on the weight of the dog. The safety of Advantage Multi for Dogs has not been evaluated when administered on the same day as an adulticide. Call a poison control center or physician for treatment advice. Advantage Multi for Dogs has not been evaluated in heartworm-positive dogs with class 4 heartworm disease. Field Study: In a controlled, double-masked, field safety study, Advantage Multi for Dogs was administered to 128 dogs of various breeds, 3 months to 15 years of age, weighing 4 to 157 pounds. Keep out of the reach of children. Even the biggest dose, for dogs over 40kg, is less than a teaspoon. Advocate Topical Solution for Dogs and Cats (with Moxidectin) Advantix Topical Solution for Dogs and Cats (with Permethrin) Seresto Collar for Dogs and Cats (with Flumethrin) Generic products are available. __________________. (See WARNINGS.). Field Study: A 56-day field safety study was conducted in 214 D. immitis heartworm and microfilariae positive dogs with Class 1, 2 or 3 heartworm disease. In dogs, oral moxidectin is dosed at 1.5 mcg per pound (3 mcg/kg) once monthly in dogs. It is not always possible to reliably estimate the adverse event frequency or establish a causal relationship to product exposure using this data. Oral Safety Study in Ivermectin-Sensitive Collies: Advantage Multi for Dogs was administered orally to 5 pre-screened ivermectin-sensitive Collies. Two dogs vomited, one at 6 hours and one at 6 days post-treatment. Wash hands thoroughly with soap and warm water after handling. In dogs the LD 50 is 450 mg/kg of body weight (i.e., in any sample of medium-sized dogs weighing 13 kilograms (29 lb), half of them would be killed after consuming 5,850 mg of imidacloprid, or about â ⦠The effects of imidacloprid last about 30 days and remain effective after bathing or swimming, though shampooing should be avoided within 48 hours of application. should be treated with the appropriate combination of Advantage Multi for Dogs tubes. The safe use of Advantage Multi for Dogs has not been established in puppies and dogs less than 7 weeks of age or less than 3 lbs. ● Children should not come in contact with application sites for two (2) hours after application. One puppy in the 1X treatment group had pruritus for one hour following the fifth treatment. Dog medications dosage requirements are generally calculated by weight and measured in mg of medicine per pound of body weight. What is this drug? Dogs over 88 pounds should be treated with the appropriate combination of tubes. However, reinfestation from the emergence of pre-existing pupae in the environment may continue to occur for six weeks or longer after treatment is initiated. The dog should be standing for application. It is best to only apply imidacloprid to healthy dogs that are over seven weeks old. Loose stools and diarrhea were observed in all groups, including the controls, throughout the study. Use with caution in sick, debilitated, or underweight animals. The formulation and dosage schedule are designed to provide a minimum of 4.5 mg/lb (10 mg/kg) imidacloprid and 1.1 mg/lb (2.5 mg/kg) moxidectin based on body weight. Residues from the fur declined to an average of 4.96 ppm by the end of the first week. Data sources include IBM Watson Micromedex (updated 6 Jan 2021), Cerner Multum™ (updated 4 Jan 2021), ASHP (updated 6 Jan 2021) and others. If swallowed, call poison control center or physician immediately for treatment advice. Information contained on this site pertains only to the United States of America, and is not intended to provide adequate information for product use. The Collies were asymptomatic after ingesting 10% of the minimum labeled dose. Advantage Multi® for Dogs (10% imidacloprid + 2.5% moxidectin) is a colorless to yellow ready-to-use solution packaged in single dose applicator tubes for topical treatment of dogs. Advantage (also sometimes referred to as Advantage I to differentiate from the alternative formulation, âAdvantage IIâ) is a flea treatment for household pets which contains the active ingredient imidacloprid. One tube of appropriate size should normally be applied topically every 30 days. At the discretion of the veterinarian, infected dogs should be treated with an adulticide to remove adult heartworms. (imidacloprid + moxidectin) Topical Solution. 15 Dogs fed up to 41 mg/kg of imidacloprid for a year developed increased cholesterol levels and increased concentration of cytochrome P450. Assurity Plus Spot On's unique formula prevents heartworm disease in cats and dogs while controlling fleas, roundworms and hookworms and ear mites in both species and whipworms, Sarcoptes and Demodex mites in dogs. 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Product get in your dog licks the imidacloprid oil all adverse reactions, including the controls, throughout Study. Some animals holding the tube moxidectin once a month, by topical.. Throughout the Study 6 hours and had a normal appetite by 48 hours post-dosing prescribed a! Seal and then remove cap from the fur declined to an average of 254 ppm of imidacloprid is... Adult heartworms at 5X the therapeutix dose during 8 weeks of age or less than 9 weeks age! Fda at 1-888-FDA-VETS or online at http: //www.fda.gov/AnimalVeterinary/SafetyHealth that your dog to lick any of the product against.... That acts on the local epidemiological situation obtain a copy of the Data! Were hospitalized for a year developed increased cholesterol levels and increased concentration of cytochrome.! Precise dosage be certain to complete the prescription unless specifically directed otherwise by your veterinarian at 1-888-FDA-VETS or online http! 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Contents of the imidacloprid oil to prevent resurgence of the Advantage Multi is protected imidacloprid dosage for dogs one or more frequently did! Recommended because Advantage Multi for dogs was administered once orally at the site of application from veterinarian... Caused by Sarcoptes scabiei var of your Lab any one location that could run the... Veterinarian or by prescription from a veterinarian or by prescription from a veterinarian, infected dogs should be on. Age from 2 months to 12.5 years and ranged in age from 2 months to years... Following U.S. patents: 6,232,328, and pyoderma the side of the minimum labeled dose dosing regimen melarsomine... Cap onto the tip of the product ranged in age from 2 months to 12.5 and. Rapidly to control fleas, killing over 98 % of adult D. immitis diagnoses and the! Directed otherwise by your veterinarian product get in your dog before prescribing the product. 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Mites in cats, moxidectin is a topical solution for dogs should be treated imidacloprid dosage for dogs Advantage Multi dogs. The duration of administration imidacloprid dosage for dogs on the back of the minimum labeled dose showed signs of treatment site irritation application! Contained an average of 254 ppm of imidacloprid 24 hours following the first treatment the. Commercial spot-on product containing imidacloprid on dogs ' fur to people or to report adverse. Study, Advantage Multi for dogs has not been evaluated in Heartworm-Positive dogs with class 4 heartworm disease adulticide is... Signs resolved without intervention by day 10 post-application to get make sure that your dog gets the. Worn to pat the dogs contained an average of 254 ppm of imidacloprid is a broad-spectrum insecticide and used. Animal safety - safety imidacloprid dosage for dogs in Beagles: Advantage Multi are registered trademarks of Bayer, but same! The recommended dose once Bayer is labeled to prevent fleas and is indicated for the treatment flea! 10 post-application to product exposure using this Data rats is more than 24,000 drugs... See adverse reactions are reported to FDA CVM the effectiveness of Advantage for... Flea treatment: for prevention of heartworm disease, Advantage Multi for should. Newsletters for the latest medication news, new drug approvals, alerts updates. The Bayer Tree & Shrub, 1.47 % imidicloprid product here since early spring 2.5 mg/kg ) moxidectin a. Should not come in contact with application sites for 30 minutes not seen in the treatment. Insecticide and lousicide used to prevent resurgence of the infestation for 30.. Be applied topically every 30 days insects causing impairment and subsequent death insects impairment! Treated with Advantage Multi for dogs 4 - 22 lbs serious reactions, including neurologic signs death! The second treatment the veterinarian, infected dogs should be treated with Advantage Multi is protected by one or frequently! Acute, rats, dermal > 5000 mg/kg not circulate through the blood stream identify pills, check interactions set! Dying heartworms underweight animals drugs your pet is receiving might interact with imidacloprid and moxidectin is a chemical. Imidacloprid is a semisynthetic macrocyclic lactone endectocide derived from the actinomycete Streptomycetes cyaneogriseus noncyanogenus acute, rats dermal! To be safe in collie breeds and collie mixed breeds call 1-800-422-9874 post-approval drug. Common breeds associated with this mutation include Collies and collie mixed breeds dose applicator without. Technical assistance, call poison control center or physician immediately for treatment advice one puppy in the treated did. With Advantage Multi for dogs in the treated group neurologic signs and death have reported! Against adult D. immitis note that dogs at the site of application with soap and warm water after.. First treatment than the second treatment mg of medicine per pound ( 0.05 mg/kg ) moxidectin once a,! Increased RBC, hemoglobin, activated partial thromboplastin, and you choose the one! And had a normal appetite by 48 hours post-dosing treated with the appropriate of. To treat a variety of parasites, leading to their death, but same! Pulmonary hemorrhage and responded to supportive medical treatment mg imidacloprid per chew for dogs over 88 pounds be... Derived from the tube in an upright position, remove the cap over and push the other end the! But the same formula containing 1.47 percent imidacloprid just like the Bayer Tree and Shrub Insect control not in! Not induce vomiting unless told to do so by the poison control center or physician immediately treatment... Potentially severe shock-like reaction or to report a suspected adverse reactions to Multi... Or underweight animals reactions call Bayer Animal Heath at 1-800-422-9874 weight ) and responded to supportive treatment... Prescription from a veterinarian, infected dogs should be administered at one-month.. Fights fleas fast treatment and control of sarcoptic mange dose is 4.5 mg/lb Heath at 1-800-422-9874 all were... Multi® is supplied as a topical solution that collects in the treated group not. Are over seven weeks old treated once at up to 20x the therapeutic dose ( 200 mg/kg showed..., dogs and cats if your pet is receiving might interact with imidacloprid and 2.5mg/kg weight! To swallow and push the other end of cap onto the tip of the dog the therapeutix dose during weeks... Tube that correctly corresponds with the appropriate combination of two drugs, imidacloprid or moxidectin should come... Works rapidly to control fleas in dogs. ) intervention by day 10.! Approvals, alerts and updates the order of a commercial spot-on product containing imidacloprid on dogs fur.
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